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The effects of magnesium on angiotensin II (Ang II)-induced contraction in isolated rat coronary artery were studied. In Ca(2+)-free medium containing 2 mmol/l EGTA, Ang II (1 nmol/l-1 mumol/l) produced concentration-dependent contractions in the artery precontracted with 1 mumol/l phenylephrine. Magnesium (1 mmol/l) inhibited the Ang II-induced contraction. In contrast, this concentration of magnesium had no effect on the contractile response to Ca2+ (100 nmol/l). Nifedipine (1 mumol/l) partially inhibited the contractile response to Ang II. The inhibitory effects of magnesium were partially inhibited by nifedipine. We concluded that the inhibitory effect of magnesium on Ang II-induced contraction in rat coronary artery was due to the blockage of Ca2+ influx through voltage-dependent calcium channel.The present invention relates to processing of electronic mail and more particularly to a method and apparatus for re-organizing electronic mail messages.
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